GenBank–GISAID Deduplication and Artifact Masking in Viral Genomics

Integrating viral genomes across GenBank and GISAID is hindered by unlinked duplicate records and lab-specific sequencing errors. Two new open-source tools—G2G matcher and LSBFILT—automate cross-database deduplication and artifact masking, nearly doubling molecular clock signal (R2 from 0.35 to 0.68) in chikungunya virus phylogenies.